Define "significant". Many, many people are very happily using microformats to interact with one another. Micro.blog is built on microformats. Not enough for you?
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Have you taken a look at indieweb.org? There are people doing lots more than hinting.
, Oct 01 2018 on twitter.com
Also on: @EatPodcast
They’re niche. Not self-sufficient. You can’t build a modern app on microformats alone.
One usecase of microformats I’m familiar with, is hints for web scrapers - I.e. embedding machine-readable data into HTML.
Zvi, Oct 01 2018 on twitter.com