This one is really interesting, and had never occurred to me. Not that I have much choice when changing continents.
PROPERLY BREAKING UP A FLIGHT JOURNEY
Simple rule, I’ve learned the hard way: 2 equal length legs of a journey are far better than one long leg and one short one. If the entire world is conspiring against you, and you cannot get a non-stop flight, pick the one with the most equal durations of flying times and try to get a 2 hour layover. That’s enough to pee, stretch, eat, and not stress if your incoming flight is delayed. Also: it’s always better to fly in and out of larger airports as there’s far better food options.